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Glutathione

• Vast amounts of this vital antioxidant is necessary every nanosecond of the day to quench the trillions of free radicals formed in cellular reactions 
• Glutathione is an essential cofactor for Nitric Oxide Synthase (NOS)⁵ the enzyme that generates Nitric Oxide for blood vessel relaxation to enhance blood flow and vascular muscle relaxation.
• Without a strong antioxidant system, your cells are damaged by free radicals produced from toxic compounds like alcohol or during the metabolism of food or in other biochemical reactions 
• N-Acetylcysteine (NAC) is one way to ensure you have enough glutathione available

Inflammation 

• Drives many a disease state 
• Through the generation of glutathione, N-Acetylcysteine (NAC) can dampen down inflammatory reactions 
• Many chronic disease states such as Asthma, Diabetes, Alzheimer's Disease, COPD, Heart and vascular disease, Many Cancers, Rheumatic Disease states and Autoimmunity to name a few are driven by inflammation 

Cell Multiplication

• Significant deficiency states interfere with cell death (apoptosis) allowing cells to survive longer than they should and inappropriate proliferation 
• This is important for disease states like Endometriosis 

Liver Biotransformation (Detoxification) Pathways 

• Glutathione and Glutathionation are important in Phase-II biotransformation to remove dangerous toxic compounds created in the body or coming from the environment. 
• Glutathione is important in getting rid of xenobiotics (foreign chemicals), carcinogens and heavy metals such as mercury
• Phase-1 & Phase-2 reactions helps you metabolize drugs, toxic compounds in your diet, transform hormones for excretion. 
• A good multivitamin will help support Phase-1 reactions and NAC will help support Phase-II reactions

Phase-1 & Phase-2 Biotransformation Pathways

Psychiatric Disorders

• N-Acetylcysteine (NAC) has been shown in numerous studies to have efficacy for disoreders such as major depressive disorderAlzheimer's disease, bipolar disorder, schizophrenia, obsessive-compulsive disorder,some drug addictions like Cocaine, and even epilepsy (progressive myoclonic)^{1, 2}.
• Inflammation drives many disease states and the brain is simply an organ in the body that does not live in isolation to the rest of the body. It too can suffer the ravages of inflammation caused by poor diets or bad lifestyle choices. 
• From Sarris et al - "Although the determinants of mental health are complex, the emerging and compelling evidence for nutrition as a crucial factor in the high prevalence and incidence of mental disorders suggests that diet is as important to psychiatry as it is to cardiology, endocrinology, and gastroenterology²."

Lung Disorders

• N-Acetylcysteine is a known mucolytic. In other words it loosens phlegm and this can be very beneficial in lung problems like asthma or chronic obstructive pulmonary disease (COPD)
• NAC has significant activity against the Influenza-A virus¹

Nitric Oxide (NO) 

• N-Acetylccysteine supports Nitric Oxide (NO) formation and helps protect Nitric Oxide from free radical damage⁴. 
• Glutathione is a key factor in the production of Nitric Oxide⁵
• Nitric Oxide (NO) dilates blood vessels and helps support healthy blood pressure levels. 
• L-Citrulline is an excellent promoter of Nitric Oxide through the generation of L-Arginine and it is L-Arginine that is the basis for Nitric Oxide (NO) production 

L-Citrulline

Erectile Dysfunction (ED)

• ED often accompanies heart and blood vessel disease 
• ED is a common problem associated with prediabetes or diabetes 
• For ED often Cialis^® or Viagra^®   is given but these can fail if there is not enough Nitric Oxide available to start the whole biochemical cascade involved in erection 
• An excellent integrative approach will be to use L-Citrulline in combination with Cialis^® or Viagra^®, starting with a small amount initially 

L-Citrulline
N-Acetylcysteine (NAC)